Title: Santa Cruz de la Sierra Vacation Packages 2026 from $1,205 | Expedia.com [Santa Cruz de la Sierra Travel Guide](https://expedia.com/Santa-Cruz-De-La-Sierra.dx6356838)[Hotels in Santa Cruz de la Sierra](https://expedia.com/Santa-Cruz-De-La-Sierra-Hotels.d6356838.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz de la Sierra](https://expedia.com/Santa-Cruz-De-La-Sierra-Vacation-Rentals.d6356838.Travel-Guide-VacationRentals)[Flights to Santa Cruz de la Sierra](https://expedia.com/Cheap-Flights-To-Santa-Cruz-De-La-Sierra.d6356838.Travel-Guide-Flights)[Car Rentals in Santa Cruz de la Sierra](https://expedia.com/Car-Rentals-In-Santa-Cruz-De-La-Sierra.d6356838.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6356838/d51eab97-c49d-4664-b787-8b19a64ced01.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Santa Cruz de la Sierra Vacations from $1,205 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## The Latest Santa Cruz de la Sierra vacation packages Price found within the past 48 hours. Click for updated prices. ![Home Art Apartments Salamanca ](https://images.trvl-media.com/lodging/47000000/46250000/46250000/46249972/afb2c641_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Home Art Apartments Salamanca Salamanca $1,205 per person Apr 21 - Apr 27 found 1 day ago Roundtrip flight included Los Angeles (LAX) to Madrid (MAD) 9/10 Wonderful! (95 reviews) Location is great. It is very clean and has everything you need. However, the shower leaked so much it was difficult to keep up when 3 people needed to shower and toaster did not work. I contacted management and nothing was done. Overall it was good. Reviewed on Jan 3, 2026 ![Hotel Atlantico Madrid](https://images.trvl-media.com/lodging/1000000/30000/26500/26417/040309d8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Atlantico Madrid Madrid Centro Save 100% on your flight $1,424 per person Apr 11 - Apr 17 found 1 day ago Roundtrip non-stop flight included Newark Liberty Intl. Airport (EWR) to Madrid (MAD) 9.8/10 Exceptional! (2,186 reviews) Very central location in Madrid. Right across from a subway station. Easy to catch taxi also in front of the hotel. It is a busy thorough fare with alot of access to stores and restaurants. It is the touristy area of the city so keep that in mind if you are looking to be in a quieter area. I was on the 4th floor, but couldn't hear much noise. Rooms are very clean and great condition. Great housekeeping. Staff overall friendly. Overall great hotel. Lobby area and public spaces need some updating and would be my only comment about furnishings and not having a coffee maker in the rooms are the only two slight comments about the accomodations. Reviewed on Mar 4, 2026 ![Hotel Mayerling](https://images.trvl-media.com/lodging/3000000/2880000/2876500/2876459/285ac20a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Mayerling Madrid Centro $1,382 per person May 19 - May 22 found 1 day ago Roundtrip non-stop flight included Los Angeles (LAX) to Madrid (MAD) 8.8/10 Excellent! (1,001 reviews) Staff employees were courteous and helpful. Location was perfect, centric, close to train stations and places of interest such as Plaza Mayor. Free coffee and tea are a plus. Room needs some improvements, tiles right outside of the shower were loose. Reviewed on Feb 22, 2026 ![Relais & Châteaux Hotel Orfila](https://images.trvl-media.com/lodging/1000000/580000/571000/570971/53bece4a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Relais & Châteaux Hotel Orfila Chamberí $1,935 per person May 19 - May 22 found 1 day ago Roundtrip non-stop flight included Los Angeles (LAX) to Madrid (MAD) 9.8/10 Exceptional! (565 reviews) Helpful staff Quiet upscale location Reviewed on Dec 29, 2025 Don't see what you're looking for? See all available trips from Columbus to Santa Cruz de la Sierra [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-05/2026-04-12/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=null&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_6356838) ## Santa Cruz de la Sierra Hotel Deals ![Rural house (full rental) El Olivar del Marqués for 26 people](https://images.trvl-media.com/lodging/33000000/32870000/32866900/32866897/3965424d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rural house (full rental) El Olivar del Marqués for 26 people Santa Cruz de la Sierra Cáceres [Get rates](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=32866897&PinnedHotelID=32866897&HadPinnedHotel=true®ionId=6356838) [](https://expedia.com/Hotel-Search?startDate=3%2F19%2F2026&endDate=3%2F20%2F2026&selected=32866897&PinnedHotelID=32866897&HadPinnedHotel=true®ionId=6356838) ![Parador de Trujillo](https://images.trvl-media.com/lodging/2000000/1140000/1134900/1134802/ff1548e6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Parador de Trujillo Santa Beatriz de Silva 1 Trujillo Caceres Fully refundableReserve now, pay when you stay $75 nightly $83 total Mar 17 - Mar 18 Total with taxes and fees 9.2/10 Wonderful! (225 reviews) Very nice hotel, good parking, well located, Reviewed on Nov 18, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F17%2F2026&endDate=3%2F18%2F2026&selected=1134802&PinnedHotelID=1134802&HadPinnedHotel=true®ionId=6356838) ![Eurostars Palacio Santa Marta](https://images.trvl-media.com/lodging/2000000/1150000/1142400/1142399/38cf34e0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Eurostars Palacio Santa Marta Calle Ballesteros 6 Trujillo Caceres Fully refundableReserve now, pay when you stay $69 nightly $75 total Mar 8 - Mar 9 Total with taxes and fees 9.2/10 Wonderful! (333 reviews) This hotel is absolutely fabulous! Highly recommend!!!! It is an old palace, our room was spacious, beds comfortable, beautiful views, location is perfect! The staff is friendly and professional. If I ever come to Trujillo again I will certainly stay here! Reviewed on Jan 8, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F8%2F2026&endDate=3%2F9%2F2026&selected=1142399&PinnedHotelID=1142399&HadPinnedHotel=true®ionId=6356838) [See all 83 properties in Santa Cruz de la Sierra](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F6%2F2026&endDate=3%2F7%2F2026®ionId=6356838) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Santa Cruz de la Sierra Vacation Packages ## Santa Cruz de la Sierra Essential Information | Language | Spanish | | --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | Euros | | Local Welcome | ¡Hola! | | Local Goodbye | Adiós | | Population | 310 | | Max Temp Winter | 55ºF | | Max Temp Summer | 90ºF | | Top Sights | [Trujillo Castle](https://www.expedia.com/Trujillo-Castle-Trujillo.d6121314.Vacation-Attraction), [Juan Pizarro de Orellana Palace](https://www.expedia.com/Juan-Pizarro-De-Orellana-Palace-Trujillo.d553248621533072002.Vacation-Attraction) and [Palace of the Marquis of the Conquest](https://www.expedia.com/Palace-Of-The-Marquis-Of-The-Conquest-Trujillo.d553248621533072006.Vacation-Attraction) | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) ## Frequently asked questions ### How much does a Santa Cruz de la Sierra vacation package cost? ### What are the cheapest months to go to Santa Cruz de la Sierra? ### How many days is enough for Santa Cruz de la Sierra? ### How to find the best Santa Cruz de la Sierra package deals? ### Is it cheaper to book a Santa Cruz de la Sierra vacation as a package? ### When to book a vacation package to Santa Cruz de la Sierra? ### Does Expedia offer Book Now, Pay Later Santa Cruz de la 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