Santa Cruz de la Sierra Vacations from $1,038
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
The Latest Santa Cruz de la Sierra vacation packages
Price found within the past 48 hours. Click for updated prices.
Nômade Temple Madrid
Madrid Centro
$1,694
per person
Oct 30 - Nov 5
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Madrid (MAD)
9.6/10 Exceptional! (70 reviews)
Highly recommended, nice place to stay and very attentive and professional staff
Reviewed on Sep 7, 2026
BLESS Madrid - The Leading Hotels of the World
Salamanca
$2,036
per person
Oct 30 - Nov 5
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Madrid (MAD)
9.2/10 Wonderful! (725 reviews)
Beautiful hotel in great location. Helpful staff, spacious room, very comfortable bed, great bathroom, excellent breakfast. Very convenient taxi stand outside hotel. Great shopping and restaurants in walking distance
Reviewed on Aug 27, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz de la Sierra
View all tripsSanta Cruz de la Sierra Hotel Deals
Rural house (full rental) El Olivar del Marqués for 26 people
Santa Cruz de la Sierra Cáceres
Parador de Trujillo
Santa Beatriz de Silva 1 Trujillo Caceres
Fully refundableReserve now, pay when you stay
$98 nightly
$108 total
Sep 16 - Sep 17
Total with taxes and fees
9.2/10 Wonderful! (244 reviews)
"Car parking, first you need to park in the road, then check in & then move your car to the car park after reception opens the gate which is not too quickly !! We checked in but were not given the wi-fi password and there is no information in the room so we had to return to reception. Breakfast - ..."
Reviewed on Aug 18, 2026
Hotel Izan Trujillo
Plaza del Campillo, 1 Trujillo Caceres
Fully refundableReserve now, pay when you stay
$91 nightly
$101 total
Oct 8 - Oct 9
Total with taxes and fees
8.6/10 Excellent! (216 reviews)
"Nice hotel with a secure room for cycles for those on tour like me. Nice rooms and good facilities. Restaurant is good but also great places to eat on the Plaza."
Reviewed on Aug 25, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santa Cruz de la Sierra Vacation Packages
Santa Cruz de la Sierra Essential Information
Language | Spanish |
|---|---|
Currency | Euros |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Population | 310 |
Max Temp Winter | 55ºF |
Max Temp Summer | 90ºF |
Top Sights | Trujillo Castle, Juan Pizarro de Orellana Palace and Palace of the Marquis of the Conquest |
More vacations you might like
Frequently asked questions
How much does a Santa Cruz de la Sierra vacation package cost?
You can snap up a vacation package to this top destination from $1,038 on Expedia. However, how much your vacation to Santa Cruz de la Sierra costs will depend on factors like your hotel choice, season and length of stay.
What are the cheapest months to go to Santa Cruz de la Sierra?
February, November and December are great times to look for cheap Santa Cruz de la Sierra vacation packages. Opting to travel in quieter months means you'll typically find reduced prices on flights and hotels.
How many days is enough for Santa Cruz de la Sierra?
The ideal length of your Santa Cruz de la Sierra vacation depends on what you'd like to do and see. Generally, a handful of days to a week will give you plenty of time to go to all the leading sights and explore some hidden spots along the way.
How to find the best Santa Cruz de la Sierra package deals?
Use Expedia's filters to find some of the best Santa Cruz de la Sierra package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your adventure for midweek, or search for Santa Cruz de la Sierra package deals in the low season. Play around with your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to lock in your vacation package as soon as possible.
Is it cheaper to book a Santa Cruz de la Sierra vacation as a package?
An Expedia vacation package could land you great savings when compared to arranging hotels and flights separately. Better still, you can customize your Santa Cruz de la Sierra getaway to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Santa Cruz de la Sierra?
If you're planning a spontaneous Santa Cruz de la Sierra getaway, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can find incredible deals on your hotels and flights by booking ahead.
Does Expedia offer Book Now, Pay Later Santa Cruz de la Sierra vacation packages?
If you're like us, you love going away but don't love the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the total cost of your Santa Cruz de la Sierra vacation across 3, 6 or 12 months. There are also no hidden costs or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.
Explore a world of travel with Expedia
- Cabin Rentals in Trujillo
- Gay friendly Hotels in Trujillo
- Hostels in Arroyomolinos de Montanchez
- Hotels near Trujillo Castle
- Conquista de la Sierra Hotels
- Arroyomolinos de Montanchez Hotels
- Miajadas Hotels
- Hotel Wedding Venues Hotels in Trujillo
- Hotels with Free Breakfast in Trujillo
- Resorts & Hotels with Spas in Trujillo
- Barcelo Hotels in Trujillo
- 5 Star Hotels in Trujillo
- Hotels near Museo de Vino y Queso
- Botija Hotels
- Santa Cruz de la Sierra Hotels
- La Cumbre Hotels
- Trujillo Hotels
- Cottages in Trujillo
- Logrosan Hotels
- Trujillo Castle
- Pizarro House Museum
- Church of Santa Maria la Mayor Trujillo
- Palacio de la Conquista
- Visit Herguijuela
- Juan Pizarro de Orellana Palace
- Visit Montanchez
- Visit Torrequemada
- San Martin Church
- Visit Trujillo
- Visit Berzocana
- Visit Madrigalejo
- Visit Arroyomolinos de Montanchez
- Iglesia San Juan Bautista
- Visit Garciaz
- Visit Plasenzuela
- Plaza Mayor
- Visit Santa Marta de Magasca
- Visit Madronera
- Visit Logrosan
- Visit Miajadas
- Palace of the Dukes of San Carlos
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
